Journal of Korean Society of Medical Ultrasound 1997;16(4): 327-334.
Correlation between the Resistive Index of the Doppler Sonography and Serum Creatinine Level in Experimentally Induced Crescentic Glomerulonephritis in Rabbits.
1Department of Radiology, Hallym University College of Medicine, Korea. 2Department of Internal Medicine, Hallym University College of Medicine, Korea. 3Department of Pathology, Hanyang University College of Medicine, Korea.
Published online: January 1, 2001.
ABSTRACT
PURPOSE: To evaluate the correlation between the resistive index from renal Doppler sonography and serum creatinine level in crescentic glomerulonephritis (CCN) induced by the anti-glomerular basement membrane Ab administration in rabbits. MATERIALS & METHODS: CGN was induced in six rabbits by anti-glomerular basement membrane Ab administration. Doppler sonography was performed before administration, and 1, 4, 7, 15, 45 days in all rabbits and 113 days in three of six rabbits after administration. Blood samples for measuring serum creatinine were obtained and the degree of renal crescents was evaluated in the same time sequences. RESULTS: Renal resistive index was gradually increased after anti-CBM Ab administration. Serum creatinine level began to increase at 4 days and peaked at 45 days. Crescents began to form at 4 days and peaked at 15 days. Fibrosis began to appear from 15 days and gradually increased. There was a linear correlation between resistive index of the renal Doppler sonography and serum creatinine level, with a correlation coefficient of 0.47. There was no linear correlation between resistive index and crescents percent, with a correlation coefficient of 0.62. CONCLUSION: This study suggests that renal resistive index may be a useful in evaluating renal function and predicting the course of the CGN.
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