Renal growth slope in children with congenital and acquired solitary functioning kidneys
Seung Myeon Choi1 , Hyun Joo Shin1 , Haesung Yoon1 , Myeongjee Lee2 , Yong Seung Lee1 , Sang Won Han1 , Mi-Jung Lee1
1Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea
2Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea
Corresponding Author: Mi-Jung Lee ,Tel: 82-2-2228-7400, Fax: 82-2-393-3035, Email: mjl1213@yuhs.ac
Received: February 26, 2020;  Accepted: September 12, 2020.  Published online: September 12, 2020.
ABSTRACT
Purpose:
To analyze the renal growth slope in children with congenital (unilateral renal agenesis as Agenesis group and multicystic dysplastic kidney [MCDK] as MCDK group) and acquired (nephrectomy associated with renal tumors as Nephrectomy group) solitary functioning kidneys.
Methods:
This retrospective study included all renal ultrasonography examinations performed in children in the Agenesis, MCDK, or Nephrectomy group between September 2002 and February 2019. We reviewed the images and recorded the contralateral kidney size only when there was no focal lesion. Linear mixed model or piecewise linear mixed model analyses with a 24-month time point were performed to compare the groups.
Results:
There were 132 patients, including 26 patients in the Agenesis group, 35 in the MCDK group, and 71 in the Nephrectomy group. The Nephrectomy group showed the largest baseline kidney size (7.4 cm vs. 5.3 cm in the Agenesis [p < 0.001] and 5.2 cm in the MCDK [p < 0.001] groups) and the smallest overall growth slope (0.04 cm/month vs. 0.06 cm/month in the Agenesis [p = 0.004] and 0.07 cm/month in the MCDK [p < 0.001] groups). However, considering the time point of 24 months reaching adult renal function, there were significant changes in slope, from 0.1 cm/month before 24 months of age to 0.03 cm/month after 24 months of age in all three groups (p < 0.001) without difference between the groups.
Conclusion:
There are significant changes in renal growth slope before and after 24 months of age without difference between congenital and acquired solitary functioning kidneys in children.
Keywords: Solitary kidney; Unilateral renal agenesis; Multicystic dysplastic kidney; Nephrectomy; Ultrasonography
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