Depattment of Internal Medicine, Wonju College of Medicine, Yonsej University, Wonju, Korea
ABSTRACT
OBJECTIVE : Metoclopramide is known to lower the intravariceal flow by raising the lower esophageal sphincterpressure and consequently decreases the portal blood flow. So we designed this study to assess the effect ofmetoclopramide on portal blood flow in cirrhotic patients using pulsed Doppler system. SUBJECTIVES AND METHODS :By using pulsed Doppler ultrasound, portal blood velocity, diameter of the portal vein, portal blood flow, bloodpressure and pulse rate were measured at 15, 30 and 60 minutes after administration of 20mg metoclopramide in 16cirrhotic patients and compared with the basal values. In order 10 cirrhotic patients, normal saline wasadministrated, and the above mentioned parameters were measured. RESULTS : Wothin 15 minutes after intravenousadministration of 20mg metoclopramide, portal blood velocity and portal blood flow decreased significantly, from12.45+2.64 to 11.80+2.55cm/sec and from 1006.3+407.1 to 974.4+414.7ml/min, respectively(P<0.05). In placebo group,there was no significant change in measured parameters after administration of normal saline. CONCLUSION : Theseresults support the hypothesis that metoclopramide significantly decreases the portal blood flow transiently incirrhotic patients with portal hypertension.
Print
facebook
twitter
Linkedin
google+
Download Citation
PDF Links
Full text via DOI 
