Journal of Korean Society of Medical Ultrasound 1996;15(1): 1-9.
Experimental Study of Percutaneous Ethanol Injection in the Rabbit Liver : Correlations Between Sonography andPathology
Hye Won Lee, Yup Yoon, Young Tae Ko, Joo Won Lim, Youn Wha Kim, Jae Hoon Lim
Department of Diagnostic Radiology, Kyung Hee University Hospital1, Department of Pathology, Kyung Hee University Hospital2 Department of Radiology, Samsung Medical Center3
ABSTRACT
PURPOSE : To investigate the sonographic change and histopathologic correlation after percutaneous ethanolinjection(PEI) of normal rabbit liver. MATERIAL & METHODS : Seven rabbits with normal livers were injected ethanolpercutaneously under the guidance of ultrasound. Ethanol was injected to five rabbit livers at two different siteswith one week interval in two week time period. The echogenecity of the lesion was compared with that of theadjacent normal liver parenchyma and classified into hypo-, iso-, and hyperechoic pattern. The resected specimenswere analyzed according to the presence of coagulation necrosis, liquefactive necrosis, and granulation tissue.RESULTS : Sonography after PEI showed hyperechoic focus in all initial injection site which became isoechoic tothe surrounding liver parenchyma with time, except for one case. However, one of the lesions became hypoechoic ina week. The isoechoic lesions on sonography were coagulation necrosis and granulation tissue on pathologiccorrelation. There was also more severe, periportal fibrosis within parenchyma adjacent isoechoic lesion, whichbecame abundant with respect to time. The hypoechoic lesion was correlated with liquefactive necrosis. CONCLUSION: Histopathologic findings of normal rabbit livers after PEI are coagulation necrosis and granulation tissue.Although the histopathologic changes become progressive with time, the sonographic findings remain isoechoic tothe surrounding liver parenchyma. Hypoechogenecity due to liquefactive necresis may be helpful to differentiatethe lesion from normal hepatic parenchyma.
Keywords: Alcohol, Liver. Sonography, Liver. Interventional procedure
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