Assessing the short term effects of radiotherapy on shear modulus of common carotid artery as a new biomarker of radiation-induced atherosclerosis
Alireza Mohammadkarim1, Manijhe Mokhtari-Dizaji1 , Ali Kazemian2, Hazhir Saberi3, Nilofar Ayobi Yazdi3, Mahbod Esfahani4
1Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Ira, Tehran, Iran
2Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
3Department of Radiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
4Department of Radiation Oncology, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
5Department of Medical Physics, Faculty of Medical sciences, Semnan University of Medical Sciences , semnan, Iran
Corresponding Author: Manijhe Mokhtari-Dizaji ,Tel: 00989123234205, Fax: 009882883828, Email: mokhtarm@modares.ac.ir
Received: February 13, 2021;  Accepted: April 26, 2021.  Published online: April 26, 2021.
ABSTRACT
Purpose:
The purpose of this study was to investigate the incidence of short-term atherosclerosis in common carotid arteries the following radiotherapy.
Methods:
The mean doses to arteries were 49.30±15.73 Gy. A computational ultrasound method was introduced to investigate the elastic modulus. Ultrasonography was performed at 2-3 cm inferior to the bifurcation region before and after the radiotherapy process and sequential images were extracted from an artery video. The instantaneous movement of the arterial wall in radial and longitudinal directions was extracted by the implementation of the maximum gradient and the block matching algorithms, respectively.
Results:
There is a significant difference between systolic blood pressure before and after radiotherapy (p<0.05). There are a significant decrease in the systolic and the end-diastolic diameters of irradiated relative to non-irradiated arteries (P<0.05). A significant difference in shear modulus of irradiated and non-irradiated arteries was demonstrated by 3.10±2.03 kPa versus 1.38±0.98 kPa (P<0.05). The results exhibited that the shear and Young modules of radiation-induced arteries were 2.25±1.50 and 1.57±0.59 times relative to pre-irradiation.
Conclusion:
Arterial shear modulus can be considered as a new biomarker of radiation-induced atherosclerosis in the common carotid artery.
Keywords: Ultrasonography; Carotid artery; Image processing; External radiotherapy; Shear modulus
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