Adaptive SVD filtering of HIFU interferences enables real-time ultrasound-guided therapy
Hunjong Lee1, Euisuk Chung1, Heechul Yoon2 , Tai-kyong Song1
1Sogang University, Seoul, Korea
2Dankook University, Yongin-si, Korea
Corresponding Author: Heechul Yoon ,Tel: +82-31-8005-3606, Fax: +82-31-8005-7219, Email:
Received: August 18, 2022;  Accepted: November 23, 2022.  Published online: November 23, 2022.
High-intensity focused ultrasound (HIFU) is an emerging therapeutic tool for effective thermal ablation of pathological tissue. For accurate localization of the target, and safe control of the HIFU dosage, real-time image guidance is desired during the HIFU exposure. Ultrasound imaging has a capability to guide the lesions in real-time, but is not an ideal option, as the HIFU application causes a strong interference, and thus, distorts the guidance image substantially. Thus, this study introduces singular value decomposition (SVD)-based filtering capable of restoring ultrasound harmonic images from the HIFU interferences without undesirable spectral distortion. The results experimentally validated with a custom-made phantom indicate that our approach eliminates HIFU-induced artifacts effectively, which is essential for real-time monitoring of therapeutic process.
Keywords: High-intensity focused ultrasound (HIFU); HIFU interference; singular value decomposition (SVD) filtering
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