Journal of Korean Society of Ultrasound in Medicine 2012;31(3): 151-158.
Ultrasonographic Findings of the Gallbladder in Patients with Acute Hepatitis A: Do They Have Clinical Relevance?.
Ji Young An, Hyoung Jung Kim, Dong Ho Lee, Joo Won Lim, Young Tae Ko, Bong Keun Choi
1Department of Radiology, Graduate School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, Korea. seonju98@hanmail.net
2Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
3Department of Preventive Medicine, Graduate School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, Korea.
  Published online: September 26, 2012.
ABSTRACT
PURPOSE: To determine the association of gallbladder (GB) abnormalities on ultrasonography (US) of patients with acute hepatitis A with demographic, clinical, and biochemical factors, and with other US findings. MATERIALS AND METHODS: This retrospective study was approved by our institutional review board, which waived the requirement for informed consent. We retrospectively evaluated 152 consecutive patients with acute hepatitis A who underwent US. The diagnosis of acute hepatitis A was made during acute illness by demonstrating anti-HAV of the IgM class. US images were reviewed simultaneously by two abdominal radiologists and a consensus was reached for GB wall thickening, GB collapse, lymphadenopathy, and hepatic echogenicity. The associations between demographic, clinical, biochemical, and US findings and GB wall thickening or collapse were then assessed. RESULTS: GB wall thickening was present in 123 (81%) and GB collapse in 96 (63%) of the 152 patients. Total bilirubin level and GB collapse differed significantly (p < 0.05) between patients with and without GB wall thickening. Gender ratio, total and peak total bilirubin level, and GB wall thickness differed significantly (p < 0.05) between patients with and without GB collapse. Multivariate analysis showed that GB wall thickening was associated with GB collapse and vice versa. CONCLUSION: GB wall thickening and GB collapse are common US abnormalities associated with each other in patients with acute hepatitis A. However, GB wall thickening or collapse is not associated with any demographic, clinical, or biochemical factors, or with other US findings, in patients with acute hepatitis A.
Keywords: Acute hepatitis A; Ultrasonography; Gallbladder
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