Journal of Korean Society of Medical Ultrasound 2002;21(4): 289-294.
Usefulness of Intracavitary Urokinase Injection under Sonographic Guidance in Treatment for Periappendiceal Abscess.
Jong Soo Ha, Sang Hoon Cha, Bo Kyoung Seo, Baek Hyun Kim, Hwan Hoon Jung, Taik Kun Kim, Cheol Min Park, Kyoo Byung Chung
1Department of Diagnostic Radiology, Ansan Hospital School of Medicine, Korea University, Korea.
2Department of Diagnostic Radiology Anam Hospital, Korea University, Korea.
3Department of Diagnostic Radiology Guro Hospital School of Medicine, Korea University, Korea.
  Published online: December 1, 2002.
ABSTRACT
PURPOSE: To evaluate usefulness of intracavitary urokinase injection for the treatment of small sized periappendiceal abscess which was not unsuitable for percutaneous catheter drainage. MATERIALS AND METHODS: From December 1997 to December 1999, we performed intracavitary injection of urokinase as a treatment of periappendiceal abscess in six patients. Initially, aspiration of the abscess was done using a 18 G needle under sonographic guidance. We measured the maximal length of residual abscess and injected 5000 IU of urokinase per centimeter of the diameter of the residual abscess. 24 hours after the injection of urokinase, repeated aspiration of the residual abscess was done, and follow-up sonographic examination was performed. RESULTS: The size of initial abscesses in each patients was ranged from 1.6x1.2 to 5.8x3.4cm (mean = 3.9x2.4cm), and initial volume of aspirated pus was ranged from 3 to 31 cc (mean = 11.8cc). 24 hours after the injection of urokinase, the volume of reaspirated pus was ranged from 4 to 13.5 cc (mean = 10.4cc). Follow-up sonography performed 3 to 10 days later revealed no residual abscess. The mean duration of hospitalization was 5.5 days. CONCLUSION: Intracavitary urokinase injection under the sonographic guidance can be a useful method for the treatment of small sized periappendiceal abscess which is not suitable for percutaneous catheter drainage.
Keywords: Appendix US; Appendicitis; Urokinase
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