Journal of Korean Society of Medical Ultrasound 2001;20(4): 279-286.
Experimentally Induced Acute Uric Acid Nephropathy in Rabbits: Findings of High Resolution Gray scale and Doppler Ultrasonographies.
Ik Yang, Soo Young Chung, Kyung Won Lee, Hong Dae Kim, Eun Young Ko, Mi Sook Won, Jung Woo Noh, Moon Hyang Park
1Department of Radiology, Hallym University College of Medicine, Korea.
2Department of Internal Medicine, Hallym University College of Medicine, Korea.
3Department of Pathology, Hanyang University College of Medicine, Korea.
  Published online: December 1, 2001.
PURPOSE: To evaluate changes of the high-resolution (HR) gray scale and Doppler ultrasonographic (US) characteristics of experimentally induced acute uric acid (UA) nephropathy in rabbits. MATERIALS and METHODS: Acute UA nephropathy was induced in ten rabbits using supersaturated lithium carbonate solution. The rabbits were divided in two groups. Group I consisted of five rabbits, and they were injected with a single dose of 150 ml of saturated UA over one hour. During this period, serial US studies of the kidneys of these rabbits were performed every ten minutes. Group II consisted of the remaining five rabbits, and three injections of 50 ml of saturated UA soultion were given on the first, fifth and eighth day and follow-up was done upto twenty fifth day. Sequential HR and Doppler US, renal biopsy and blood sampling were performed on day 1, 5, 8, 21, and 25 in the group II rabbits. RESULTS: In group I, HR and Doppler US examination revealed the normal resistive index without significant abnormality. On the other hand, US studies of group II showed poor renal corticomedullary differentiation, decreased renal blood flow and elevated resistive index. There was statistically significant correlation among US findings, histologic characteristics and chemical index (BUN, creatinine) of renal function. In addition, sequentially increased size and volume of the kidney were noted in both groups. CONCLUSION: HR gray scale and Doppler US characteristics of experimentally induced acute UA nephropathy in rabbits were similar to those of acute renal failure caused by other well-known causes.
Keywords: Kidney, effects of drugson; Kidney, US; Ultrasound(US), Dopplen studies; Nephritis
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