Journal of Korean Society of Medical Ultrasound 2001;20(4): 273-277.
Hyperdynamic Circulatory Changes in Liver Cirrhosis: Comparative Evaluation by Doppler Ultrasonagraphy with Normal Subjects.
Dae Wook Im, Soon Koo Baik, Jung In Suh, Jae Woo Kim, Yong Soon Park, Hyun Soo Kim, Dong Ki Lee, Sang Ok Kwon
Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Korea. skbaik@wonju.yonsei.ac.kr
  Published online: December 1, 2001.
ABSTRACT
PURPOSE: To evaluate the cardiovascular and splanchnic hemodynamic changes in patients with liver cirrhosis and to compare with those of the normal controls using Doppler ultrasonography. MATERIALS and METHODS: A total of 129 patients including 23 of Child-Pugh class A, 24 of class B, 30 of class C, and 52 of the control group were included. Cardiac output (CO), systemic vascular resistance index (SVRI), and blood flow and pulsatility index (PI) of the superior mesenteric artery (SMA) were evaluated and compared among each groups. RESULTS: CO and SMA blood flow in the cirrhotic group were significantly higher than those in the control group, and the increase in CO and SMA blood flow showed a statistically significant correlation with the degree of liver dysfunction (p<0.01). SVRI and SMA PI reflecting vascular resistance in the cirrhoic group were significantly lower than those in the control group, and the decrease in SVRI and SMA PI also showed a statistically significant correlation with the degree of liver dysfunction (p<0.01). SMA blood flow showed a statistically significant inverse relationship with SMA PI (R2=0.230) . CONCLUSION: Hyperdynamic circulatory changes such as increases in CO and splanchnic blood flow were present in patients with liver cirrhosis. These changes may contribute to the development and maintenance of the portal hypertension due to an increase in portal blood flow.an increase in portal blood flow.
Keywords: Liver, cirrhosis; Liver, US; Ultrasound(US), Doppler studies
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