Journal of Korean Society of Medical Ultrasound 2000;19(3): 161-170.
VX2 Carcinoma in Rabbit Liver: Different Radiologic Features According to Innoculation Methods.
Joon Woo Lee, Jin Wook Chung, Guk Myeong Choi, Chong Jai Kim, Se Hyung Kim, Joon Il Choi, Kyoung Ho Lee, Seung Hyup Kim, Jae Hyung Park
1Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine.
2Halla Hospital.
3Department of Pathology, Seoul National University College of Medicine.
  Published online: January 1, 2001.
ABSTRACT
PURPOSE: To investigate radiologic features about hepatic VX2 carcinoma induced by two methods, direct intra-parenchymal innoculation vs transportal approach, focus on enhancement pattern and comparison of each imag-ing modalities and innoculation methods. MATERIALS AND METHODS: VX2 carcinomas were induced in 11 rabbit livers by direct inoculation (n = 7) or infusion into mesenteric vein (n = 4). After two weeks, spiral CT, digital subtraction angiography (DSA), intravenous contrast-enhanced power Doppler sonography, intraarterial CO 2 sonography were done. The enhancement pat-terns were assessed independently and correlated with histopathologic features. RESULTS: With direct intraparenchymal innoculation, localized hepatic VX2 tumors were developed. Considering all imaging modalities, six of 7 tumors appeared peripheral hypervascularity, one hypovascularity. On patholog-ic and radiologic correlations, the enhancing portions of 4 tumors corresponded to viable tumor and pseudo-cap-sule portion, the other enhancing portions of 2 tumors corresponded to sinusoidal vascular spaces. With the transportal approaches, diffuse hepatic tumors were developed. Spiral CT and DSA revealed these tumors as marked peripheral hypervascular tumors with multiple A-P shunts. On pathologic findings, multiple thin walled sinusoidal spaces were seen at periphery of nodule. Spiral CT was superior to the other modalities in evaluation of enhancement characteristics. CONCLUSION: VX2 carcinomas in rabbit livers showed different radiologic and histopathologic features according to the innoculation methods.
Keywords: Liver neoplasms; Liver neoplasms, CT; Liver neoplasms, US; Liver neoplasms, angiography
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