Journal of Korean Society of Medical Ultrasound 2004;23(3): 137-145.
US Features of Experimentally-induced Transient Ischemia and Infarct of Renal Segmental Artery of Rabbits.
Byung Kwan Park, Seung Hyup Kim, Min Hoan Moon
1Department of Radiology, Seoul National University, College of Medicine, Korea. kimsh@radcom.snu.ac.kr
2Institute of Radiation Medicine, SNUMRC, Korea.
3Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
4Department of Radiology, Sungkyunkwan University School of Medicine, Samsung Cheil Hospital & Women's Healthcare Center, Korea.
  Published online: September 1, 2004.
ABSTRACT
PURPOSE: The goal of this study was to analyze and compare the changes in renal parenchymal morphology and cortical perfusion following transient arterial ischemia and infarct in rabbits using ultrasonography (US). MATERIALS AND METHODS: Six rabbits were divided into the ischemia (n=3)and infarct groups (n=3).In the ischemia group, a lower polar branch of the left renal artery was surgically ligated for a duration of 60 minutes and then released, in order to induce transient renal ischemia and reperfusion. In the infarct group, a lower polar branch of the left renal artery was permanently ligated without release, in order to induce renal infarction. Gray-scale and contrast-enhanced color/power Doppler US were performed in the two groups at specific times, namely before ligation, immediately after release or ligation (for the ischemia and infarct groups, respectively?), and on the 1st, 3rd, 7th, 14th and 28th postoperative days. The left kidneys of all rabbits were harvested after the last US, for the purpose of evaluating the pathologic correlations. RESULTS: In the US images, swelling, hypo- or hyperechoic areas of the involved parenchyma, tissue loss and perfusion defects were more predominant in the infarct group than in the ischemia group. In successive images, hyperechoic renal parenchyma with no reperfusion changed into renal infarct, while that with reperfusion became normal tissue.In the pathologic analysis, the specimens obtained from the ischemia group revealed mild parenchymal infarct with interstitial fibrosis, whereas those from the infarct group revealed extensive tissue loss and scarring in the involved area of the lower pole. CONCLUSION: Gray-scale and contrast-enhanced color/power Doppler US can demonstrate the morphological and hemodynamic changes in cases of renal ischemia and infarct.
Keywords: Kidney, infarction; Kidney, ischemia; Ultrasound (US), Doppler studies; Ultrasound (US), experimental
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