Evaluation of lymph node metastasis in rabbit tumor model: correlation between contrast enhanced ultrasound and pathological findings
Shin-Woo Ha1,3 , Hyun-Je Lee2 , Aesin Cho1 , Sung Il Hwang1 , Hak Jong Lee1,2
1Seoul National University, Seongnam-si, Korea
2Seoul National University Graduate School of Convergence Science and Technology, Suwon-si, Korea
3IMGT Co, Ltd. , Seongnam-si, Korea
Corresponding Author: Hak Jong Lee ,Tel: +82.31.787.7619, Fax: +82.31.787.4011, Email: hakjlee@snu.ac.kr
Received: January 30, 2019;  Accepted: June 10, 2019.  Published online: June 10, 2019.
ABSTRACT
Purpose:
To detect and evaluate metastatic lymph node (LN) for treatment planning and prognosis using by contrast enhanced ultrasound (CEUS) and microbubbles
Methods:
To make metastatic LN model, the ground VX2 tumor tissues were injected subcutaneously, just below the right hind limb of 12 rabbits. The rabbits were classified into 3 groups by the LN area (cm2): group A (n=4, >1.9), group B (n=4, 1-1.9), and group C (n=4, <1). LNs were monitored on CEUS for 10 seconds after injecting 2.5 ml of microbubbles. The percent area of metastatic LN was calculated on pathologic images and compared with CEUS images.
Results:
In group A, the mean percent area of metastasis was 40.7 ± 19.4%. In all the metastatic cases, round-shaped perfusion defects were definitely observed in CEUS images. The metastatic areas were strongly correlated with pathologic findings. Group B was 21.5 ± 14.4 %. The CEUS findings showed multiple nodular perfusion defects, clearly revealing the metastatic area. 3 out of 4 cases were positive. Group C was 9.1 ± 6.4 %. Only one case was positive on CEUS, showing a small perfusion defect.
Conclusion:
CEUS has potential to depict characteristic imaging features occurring within the metastatic lymph nodes. However, it still has limitation in early detection.
Keywords: Lymph nodes; Lymphatic metastasis; Microbubble; Ultrasonography; Diagnostic imaging
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